A Tale of Two Ages:
Deciphering Mucosal Immunity Against RSV in Infants vs. Adults
Speaker: Luan Vu, PhD
Assistant Professor at The University of Texas at San Antonio
Dr. Luan Vu earned his PhD from the University of Sydney. He has received the Parker B. Francis Fellowship at UTSA for cutting-edge immunological and multi-omics approaches to studying early-life immune responses. While at the Pasteur Institute in Ho Chi Minh City, Dr. Luan Vu significantly contributed to Hantavirus research, being the first to describe a case of Hemorrhagic Fever with Renal Syndrome in Southern Vietnam and linking Seoul virus to clinical cases and led molecular phylogenetic studies on Dengue
- Linkedin: LUAN VU
- Published Work: Luan Vu Dinh’s Bibliography
- GoogleScholar: Luan Vu Dinh
- Address: 1 UTSA Circle, Tobin Laboratory bld, Room 1205
- Phone: (210) 458 7086
- Email: luan.vu@utsa.edu
Abstract
My research unveils new mechanisms in infant RSV immunopathogenesis, revealing that IL1β significantly amplifies IL33-mediated type 2-biased RSV effects in early life. It demonstrates that IL33 significantly boosts OX40L expression on dendritic cells (DCs), thus mediating Th2-biased immunopathophysiology in RSV via OX40L/OX40 axis. A critical finding is that IL33 is essential for the activation of innate lymphoid type 2 cells (ILC2), linking elevated respiratory ILC2 levels with severe RSV in infants. Building on these discoveries, I am now delving into how early-life RSV infection influences the development of pediatric asthma, focusing on KLRG1+ILC2 cells in infants. The insights gained could pave the way for innovative strategies to prevent chronic respiratory diseases, significantly impacting public health and child welfare.
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