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New Paradigm of Proactive Health Concept: Engagement of Health Care Providers or Patients Speaker: Van Thi Nhu Ngoc, PhD Senior Scientist/Project Manager at SkillCell/Sys2diag   Dr. Van Thi Nhu Ngoc completed her PhD in Biology for Health at the CRBM, Montpellier, France, in 2013. She then joined the IINS in Bordeaux, France, for her postdoc training. In 2016, she joined the Sys2diag as principal investigator and project manager. From 2021 up to date, she has pointed as senior scientist/principal investigator and project manager at the company SkillCell. As being the scientific lead of the company, she is responsible for development of non-invasive diagnostic tools for the prevention of different diseases. Throughout her scientific trainings and professional experiences, she has acquired diverse expertise across different disciplines in biology, mastered advanced molecular biology and biochemistry tools. Together with her strong background in cell biology, human physiology and pathophysiology of chronic diseases, she leads pioneering innovative molecular assays pushing the boundary of diagnostic field. She has published a number of papers in high impact factor journals and patens.𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐩𝐫𝐨𝐟𝐢𝐥𝐞:https://www.researchgate.net/profile/Thi-Van-2/research𝐏𝐫𝐨𝐟𝐞𝐬𝐬𝐢𝐨𝐧𝐚𝐥 𝐩𝐫𝐨𝐟𝐢𝐥𝐞:https://www.linkedin.com/in/van-thi-nhu-ngoc-526b2440/https://www.linkedin.com/company/skillcell/posts/… Abstract During her presentation, Dr Ngoc shared her perspectives in how proactive care context could evolve to engage both patients and health care providers in order to improve quality of life of patients. She also emphasized on how early diagnosis could significantly benefit both patients and health care systems. Finally, she provided extensive discussion possibilities of reserving back to health from certain chronic conditions when both parties are engaged.

The 3rd Webinar of ASM-Vietnam Webinar Series: Pre-event and Main Event Registration In alignment with the objectives of ASM network, the ASM-Vietnam Webinar Series was organized with the aim to foster the development of young Vietnamese microbiologists while also serving as a conduit for global outreach for ASM. Building on the success of the 1st and 2nd webinar, we invite you to the 3rd Webinar in the series with the topic: Infection Control and Medical Microbiology. Register now Click and fill in the form attached below Register Pre-event Webinar December 14th, 2024 – 1.30 – 4.00PM (ICT) 1. Improving fungal identification from environmental and clinical sample Speaker: Dr. Thuy Duong Vu – Bioinformatics Researcher at Westerdijk Fungal Biodiversity Institute, Netherlands Abstract Fungi, with an estimated 2-6 million species, represent a vast and diverse group; yet, less than 5% of them have been described. They are essential for maintaining ecosystem health and stability, contributing to nutrient cycling, forming symbiotic relationships, facilitating decomposition, and supporting various other ecological processes. Some fungi are pathogenic and can cause severe diseases in plants, animals, and humans. Accurate identification of fungi from environmental and clinical samples is crucial for understanding the causes and consequences of environmental changes and for developing appropriate treatments for fungal diseases. This process, however, can be challenging due to the lack of comprehensive reference data and the vast number of environmental samples being generated with the rapid development of sequencing technologies, which requires computational methods that can identify fungi quickly and accurately. In my talk, I will present the fungal DNA barcode dataset generated at the Westerdijk Institute, which won the Dutch Data Prize in 2022 in the Life Sciences category for fungal identification. Additionally, I will discuss several computational methods, including AI techniques, that we have developed and applied to enhance fungal identification from environmental and clinical samples using DNA barcodes and whole fungal genomes. 2. Genomic diversity and drug resistance of Candida pathogens Speaker: Dr. Clement Tsui – Principal Scientific Officer in National Centre for Infectious Diseases in Singapore Abstract Invasive candidiasis poses a significant health concern, causing substantial morbidity among immunocompromised patients. There was increased incidence of Candida infections among patients with COVID-19 worldwide. This problem is complicated by the surge in antifungal resistance among many clinically relevant Candida spp., such as C. auris, C. glabrata, C. tropicalis, and C. parapsilosis. We have integrated whole genome sequencing (WGS) approach, population genomics analysis with conventional microbiological techniques to investigate the epidemiology, and antifungal resistance mechanisms in these pathogens in the Middle East regions. WGS data confirmed the clonal outbreak and ongoing dissemination of C. auris among various healthcare facilities in Qatar, particularly among COVID-19 patients. Similarly, WGS data revealed high genetic diversity in C. glabrata within the Qatari populations and identified signatures of recombination, inbreeding and clonal expansion within and between hospitals, including evidence for nosocomial transmission among COVID19 patients. Genome wide association studies also identified both known and novel genomic variants associated with reduced susceptibilities to fluconazole, 5-flucytosine, and amphotericin B in several isolates. In addition, we detected a clonal spread of fluconazole-resistant C. parapsilosis in Qatar, despite its variability. Understanding the genetic diversity, and epidemiology of Candida infections and antifungal resistance mechanisms is important to inform therapy and infection control strategy. Main Event (updating) December 17th, 2024 (ICT) 1. Reinventing UTI Treatment: Phages as Targeted Solutions Speaker: Dr. S.Shobana – Associate Professor at the Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, India 2. Exploring Molecular Epidemiology and Genomic Insights in Enterococci Speaker: Diana Panesso, BS, MS, PhD – Weill Cornell Medical College & Houston Methodist Research Institute  3. Infection Control; Waste Management Speaker: Dr. Muhammad Bakir Hussain – University of Lahore, Pakistan 4. Laboratory Diagnosis of Bacteremia: Current State of the Art Speaker: Dr. Nang L. Nguyen – Clinical Microbiology, Santa Clara County Health System, San Jose Register now Click and fill in the form attached below Register

Quantum vaccinomics: a platform for vaccine development against pathogens of human and veterinary importance Speaker: Juan Mosqueda, PhD Full Time Professor. Immunology and Vaccines Laboratory, Natural Sciences College, Autonomous University of Queretaro; Carretera a Chichimequillas, Ejido Bolaños, Queretaro Queretaro 76140, Mexico; joel.mosqueda@uaq.mx Abstract Vaccines are one of the most effective methods of disease prevention available. Only potable water, also considered a basic human right, has had a greater impact on people’s health than vaccines. In our group, we have focused on the development of vaccines against pathogens of human and veterinary importance for more than 20 years. We have approached this in three ways: 1. Characterizing the genes of pathogens that participate in key biological functions and can be targeted as vaccine candidates.2. Characterizing the genes of pathogens that are involved in the invasion process or sexual reproduction and can also be targeted as vaccine candidates.3. Identifying the genes of disease vectors (such as ticks) that can be targeted to reduce the biological fitness of the ticks. By combining interactomics, proteomics, and genomics tools, we have identified genes that can be included in vaccines against viruses like SARS-CoV-2 and RHDV-2, bacteria like Streptococcus agalactiae, protozoans like Babesia bovis and B. bigemina, and arthropods like the Rhipicephalus microplus tick. With the help of immuno-bioinformatics, we have identified conserved B-cell epitopes that induce neutralizing antibodies and conserved T-cell epitopes that induce cellular immune responses in vaccinated animals. Additionally, we assembled multi-epitope, multi-antigenic molecules that, were expressed as recombinant chimera proteins. The purified recombinant antigens are emulsified with adjuvants and inoculated in naive animals. We have showed that these vaccine antigens induced protection in challenged animals, and were able to be patented.Through quantum vaccinomics, we are currently laying the foundations to develop vaccines that induce protective immune responses, while being cost-effective and easy to produce.   #RCID #RCIDSeminar