Research Center for Infectious Diseases

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thayThong2

 

Le Minh Thong, PhD

P.I.

Research Interest(s)

  • Genetics, Genomics, Animal science, Molecular diagnostics
  • DNA Genotyping, DNA Sequencing, DNA analysis
  • Cloning, Cell Culture, Cell Transfection
  • Immunogenetics, Gene expression

Education

  • BS., Nong Lam University, HCMC
  • MS., Konkuk University, Seoul, Korea
  • Ph.D., Konkuk University, Seoul, Korea

Awards

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Featured Publications

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Publications

  1. Youk S, Le MT, Kang M, Ahn B, Choi M, Kim K, et al. Development of a high-resolution typing method for SLA-3, swine MHC class I antigen 3. Anim Genet. 2022 2022/02//;53(1):166-70. eng.
  2. Choi, Min-Kyeung, Minh Thong Le, Hye-Sun Cho, Juyoung Lee, Hyoim Jeon, Se-Yeoun Cha, Manheum Na, et al. “Transgenic Mice Overexpressing PG1 Display Corneal Opacity and Severe Inflammation in the Eye.” International Journal of Molecular Sciences 22, no. 4 (January 2021): 1586
  3. Le, Minh Thong, Hojun Choi, Hyejeong Lee, Van Chanh Quy Le, Byeongyong Ahn, Chak-Sum Ho, Kwonho Hong, Hyuk Song, Jin-Hoi Kim, and Chankyu Park. “SLA-1 Genetic Diversity in Pigs: Extensive Analysis of Copy Number Variation, Heterozygosity, Expression, and Breed Specificity.” Scientific Reports 10, no. 1 (January 20, 2020): 1–12.
  4. Lee, Juyoung, Minh Thong Le, Min-Kyeung Choi, Van Chanh Quy Le, Hojun Choi, Hyejeong Lee, Hyuk Song, Jin-Hoi Kim, and Chankyu Park. “Development of a Simple SLA-1 Copy-Number-Variation Typing and the Comparison of Typing Accuracy between Real-Time Quantitative and Droplet Digital PCR.” Animal Genetics 50, no. 3 (2019): 315–16. https://doi.org/10.1111/age.12785. (Co-first author)
  5. Jeon, Hyoim, Minh Thong Le, Byeongyong Ahn, Hye-sun Cho, Van Chanh Quy Le, Joori Yum, Kwonho Hong, Jin-Hoi Kim, Hyuk Song, and Chankyu Park. “Copy Number Variation of PR-39 Cathelicidin, and Identification of PR-35, a Natural Variant of PR-39 with Reduced Mammalian Cytotoxicity.” Gene 692 (April 15, 2019): 88–93. https://doi.org/10.1016/j.gene.2018.12.065. (Co-first author)
  6. Van Chanh Le, Quy, Thong Minh Le, Hye-Sun Cho, Won-Il Kim, Kwonho Hong, Hyuk Song, Jin-Hoi Kim, and Chankyu Park. “Analysis of Peptide-SLA Binding by Establishing Immortalized Porcine Alveolar Macrophage Cells with Different SLA Class II Haplotypes.” Veterinary Research 49, no. 1 (September 21, 2018): 96. https://doi.org/10.1186/s13567-018-0590-2. (Co-first author)
  7. Park, K., H. Choi, L. M. Thong, O.-J.Kwon, J.-H.Kim, H.-T.Lee, Y.-B.Kim, S.-B.Park, and C. Park. “Simple and Comprehensive SLA-DQB1 Genotyping Using Genomic PCR and Direct Sequencing.”Tissue Antigens 76, no. 4 (October 2010): 301–10. doi:10.1111/j.1399-0039.2010.01522.x.
  8. Thong, L. Minh, H. Choi, O.-J.Kwon, J.-H.Kim, Y.-B.Kim, J.-W. Oh, K. Seo, S.-C. Yeom, W.-J.Lee, and C. Park. “Systematic Analysis of Swine Leukocyte Antigen-DRB1 Nucleotide Polymorphisms Using Genomic DNA-Based High-Resolution Genotyping and Identification of New Alleles.”Tissue Antigens 77, no. 6 (June 2011): 572–83. doi:10.1111/j.1399-0039.2011.01662.x.
  9. Le, M. T., H. Choi, M.-K.Choi, D. T. Nguyen, J.-H.Kim, H. G. Seo, S.-Y.Cha, et al. “Comprehensive and High-Resolution Typing of Swine Leukocyte Antigen DQA from Genomic DNA and Determination of 25 New SLA Class II Haplotypes.”Tissue Antigens 80, no. 6 (December 2012): 528–35. doi:10.1111/tan.12017.
  10. Le, MinhThong, Hojun Choi, Min-Kyeung Choi, Hyesun Cho, Jin-Hoi Kim, Han GeukSeo, Se-Yeon Cha, KunhoSeo, HailuDadi, and Chankyu Park. “Development of a Simultaneous High Resolution Typing Method for Three SLA Class II Genes, SLA-DQA, SLA-DQB1, and SLA-DRB1 and the Analysis of SLA Class II Haplotypes.” Gene 564, no. 2 (June 15, 2015): 228–32. doi:10.1016/j.gene.2015.03.049.
  11. MinhThong Le, Dadi Hailu, HundumaDinka, DinhTruong Nguyen, Hojun Choi, Hyesun Cho, Minkyeung Choi, et al. “Genetic Diversity and mRNA Expression of Porcine MHC Class I Chain-Related 2 (SLA-MIC2) Gene and Development of a High-Resolution Typing Method.” PloS One 10, no. 8 (2015): e0135922. doi:10.1371/journal.pone.0135922.
  12. Choi, H., M. T. Le, H. Lee, M.-K.Choi, H.-S.Cho, S. Nagasundarapandian, O.-J. Kwon, et al. “Sequence Variations of the Locus-Specific 5’ Untranslated Regions of SLA Class I Genes and the Development of a Comprehensive Genomic DNA-Based High-Resolution Typing Method for SLA-2.” Tissue Antigens 86, no. 4 (October 2015): 255–66. doi:10.1111/tan.12648.
  13. Le, Thong Minh, Quy Van Chanh Le, Dung Minh Truong, Hye-Jeong Lee, Min-Kyeung Choi, Hyesun Cho, Hak-Jae Chung, et al. “Β2-Microglobulin Gene Duplication in Cetartiodactyla Remains Intact Only in Pigs and Possibly Confers Selective Advantage to the Species.” PLOS ONE 12, no. 8 (August 16, 2017).
  14. Dinka, Hunduma, and Minh Thong Le. “Analysis of Pig Vomeronasal Receptor Type 1 (V1R) Promoter Region Reveals a Common Promoter Motif but Poor CpG Islands.” Animal Biotechnology, November 9, 2017.
  15. Choi, Min-Kyeung, Minh Thong Le, Hyesun Cho, Joori Yum, Mingue Kang, Hyuk Song, Jin-Hoi Kim, Hak Jae Chung, Kwonho Hong, and Chankyu Park. “Determination of Complete Sequence Information of the Human ABO Blood Group Orthologous Gene in Pigs and Breed Difference in Blood Type Frequencies.” Gene, December, 2017.
  16. Kim, Dayeong, Nagasundarapandian Soundrarajan, Juyeon Lee, Hye-sun Cho, Minkyeung Choi, Se-Yeoun Cha, Byeongyong Ahn, Minh Thong Le et al. “Genome Wide Analysis of the Antimicrobial Peptides in Python Bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity.” Antimicrobial Agents and Chemotherapy, June 19, 2017, AAC.00530-17.
  17. Soundrarajan, Nagasundarapandian, Hye-sun Cho, Byeongyong Ahn, Minkyung Choi, Le Minh Thong, Hojun Choi, Se-Yeoun Cha, et al. “Green Fluorescent Protein as a Scaffold for High Efficiency Production of Functional Bacteriotoxic Proteins in Escherichia Coli.” Scientific Reports 6 (February 11, 2016).
  18. Cho, Hye-sun, Won Kim, Min-Kyung Choi, Minh Thong Le, HoJun Choi, Jin-Hoi Kim, Kyungtae Kim, et al. “Effects of Natural Resistance-Associated Macrophage Protein 1 and Toll-like Receptor 2 Gene Polymorphisms on Post-Weaning Piglet Survivability.”Genes & Genomics, October 23, 2015, 1–8. doi:10.1007/s13258-015-0355-5.
  19. Dinka Hunduma, Minh Thong Le, Heekyun Ha, Hyesun Cho, Min-Kyeung Choi, Hojun Choi, Jin-Hoi Kim, NagasundarapandianSoundarajan, Jin-Ki Park, and Chankyu Park.“Analysis of the Vomeronasal Receptor Repertoire, Expression and Allelic Diversity in Swine.”Genomics, October 16, 2015. doi:10.1016/j.ygeno.2015.10.003.
  20. Choi, Minkyeung, Jongin Lee, Minh Thong Le, Dinh Truong Nguyen, Suhyun Park, NagasundarapandianSoundrarajan, Kyle M. Schachtschneider, et al. “Genome-Wide Analysis of DNA Methylation in Pigs Using Reduced Representation Bisulfite Sequencing.” DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes 22, no. 5 (October 2015): 343–55. doi:10.1093/dnares/dsv017.